Acrivon is a clinical stage biopharmaceutical company discovering and developing precision oncology medicines utilizing its proprietary Generative Phosphoproteomics AP3 platform. The platform allows the company to interpret and quantify compound specific, drug-regulated pathway activity levels inside the intact cell in an unbiased manner, yielding terabytes of proprietary data and delivering rapid, actionable insights. The Generative Phosphoproteomics AP3 platform is comprised of a growing suite of powerful, internally-developed tools, including the AP3 Data Portal, converting multimodal data into structured data for generative AI analyses, the AP3 Kinase Substrate Relationship Predictor and the AP3 Interactome. These distinctive capabilities enable the company to go beyond the limitations of traditional drug discovery, as well as current AI-based target-centric drug discovery, and rapidly design highly differentiated compounds with desirable pathway effects through intracellular protein network analyses and advance these agents into the clinic for streamlined development.

Acrivon is currently advancing its lead program, ACR-368 (also known as prexasertib), a selective small molecule inhibitor targeting CHK1 and CHK2 in a potentially registrational Phase 2 trial for endometrial cancer. The company has received Fast Track designation from the Food and Drug Administration, or FDA, for the investigation of ACR-368 as a monotherapy based on OncoSignature-predicted sensitivity in patients with endometrial cancer. The FDA has granted a Breakthrough Device designation for the ACR-368 OncoSignature assay for the identification of patients with endometrial cancer who may benefit from ACR-368 treatment.

In addition to ACR-368, Acrivon is also leveraging its proprietary Generative Phosphoproteomics AP3 platform for developing its co-crystallography-driven, internally discovered pipeline programs. These include ACR-2316, the company’s second clinical stage asset, a novel, potent, selective WEE1/PKMYT1 inhibitor designed for superior single-agent activity through strong activation of not only CDK1 and CDK2, but also of PLK1 to drive pro-apoptotic cell death, as observed in preclinical studies against benchmark inhibitors. The Phase 1 trial of ACR-2316 is advancing with enrollment in the first three dose-escalation cohorts completed. Drug target engagement was observed at DL1 and 2 using the company’s clinical mass-spectrometry-based AP3 profiling, with evidence of approximate dose proportionality based on plasma pharmacokinetic analyses, and initial clinical activity with tumor shrinkage observed at DL3. The company also has a preclinical cell cycle program with an undisclosed target.

Our global team operates out of two leading life science clusters, Watertown, MA and Medicon Village in Lund, Sweden.

Position Overview:

Acrivon is seeking a confident, highly motivated, organized, and talented professional to join our team. This individual will provide administrative support to primarily the CEO, as well as needed for other C-level team members, demonstrating a high degree of sophistication, tact, and discretion dealing with information of a critical and confidential nature. S/he will provide extensive coordination and communication with our internal team, Board members, partners, and other outside parties across multiple geographies and time zones. In addition to strong interpersonal skills, to succeed in this role the individual must have outstanding computer and troubleshooting skills, particularly in Microsoft Word, Excel, PowerPoint, and virtual meeting tools such as Zoom and Teams. This individual will thrive in a fast-paced, fluid, and rapidly growing corporate environment, will be adept at multi-tasking, yet detail-oriented tofollow through and complete tasks in a timely and structured manner. The individual is a solution-oriented team player, whose actions will exemplify integrity, dependability, adaptability, and self-confidence. The position will be on site at our corporate headquarters in Watertown, MA.

Duties and Responsibilities:

• Provide calendar management for the CEO and as needed other C-level team members, often involving multiple parties, stakeholders, and time zones.
• Prioritize inquiries and requests while troubleshooting conflicts; make judgements and recommendations to ensure smooth day-to-day engagements.
• Manage meeting logistics, e.g., conference room reservations, AV/IT arrangements, catering, greeting guests, etc.; work with meeting participants to ensure that materials are provided in advance and print if needed.
• Collaborate with the direct reports, team members, and other administrative assistants of those you support to ensure smooth workflows and efficient operations.
• Owns and manages the scheduling and administrative preparations for the quarterly Board meetings.
• Help coordinating complex domestic and international travel; including travel itinerary and ensuring passport/visa/countries entry and exit requirements are met.
• Diligently manage expense reporting in a timely manner.
• Assists with preparation of reports and presentations.
• Performs other related duties as assigned.

Required Skills/Abilities:

• Life Sciences or Biotech experience with 5+ years supporting C-suite executives.
• Three key skills required include 1) detailed and accurate calendar management, 2) follow through on tasks to completion, and 3) detailed and timely expense reporting and management, ideally with Concur.
• Excellent verbal and written communication skills.
• The individual is structured, with excellent organizational skills and attention to detail.
• Excellent time management skills with a proven ability to meet deadlines and follow through with completion of tasks.
• Strong IT and computer skills, with the ability to efficiently work on applicable Microsoft platforms including Word, Excel and PowerPoint.
• Ability to function well in a high-paced environment.
• Strong interpersonal skills; “ambassador” to both internal and external stakeholders.
• Self-starter; demonstrates resourcefulness with proven ability to anticipate needs and manage multiple tasks.
• Critical thinker; demonstrates outstanding judgment and problem-solving capabilities.
• Comfortable navigating ambiguity and shifting priorities.
• Flexible “can do” attitude; able to adapt and reprioritize to shifting or competing priorities.
• High level of judgment and discretion related to sensitive and confidential information.
• Motivated by working in a fast-paced, dynamic environment.
• Willing to work outside of normal business hours when necessary.

Acrivon Therapeutics is proud to be an equal opportunity employer and to provide equal opportunities to all employees and applicants for employment without regard to race, color, religion, sex or gender identity, national origin, age, disability, sexual orientation or genetics. In addition to federal law requirements, Acrivon Therapeutics complies with applicable state and local laws governing nondiscrimination in employment.