Research Associate or Senior Research Associate, LNP Formulation
Earli
This job is no longer accepting applications
See open jobs at Earli.See open jobs similar to "Research Associate or Senior Research Associate, LNP Formulation" Sands Capital.About Earli
The mission of the Biotechnology startup Earli Inc. is large and ambitious: to detect and then cure cancer at its earliest stages, effortlessly and pain free. In other words, ‘make cancer a benign experience’. The technology which grounds the company’s efforts ushers in a new era in “synthetic biomarkers” as a novel methodology to detect cancer and then subsequently localize and then treat the cancer. The enabling technology utilizes “synthetic biomarkers” as a novel methodology to detect, localize and ultimately destroy cancer. Founded by Sam Gambhir, Cyriac Roeding and David Suhy, the company is well funded by world-class entrepreneurs and venture capital firms. Earli, Inc. is currently based in Redwood City, California.
Who You Are
- You share our same sense of dedication, scientific passion and entrepreneurial spirit
- You work well in a fast-paced and extremely focused startup environment
- You are not only smart, but clever and constantly think outside the box
- You are able to make logical decisions in an instant when there is little time to evaluate
- You are a natural communicator and relationship builder
- You stay calm under high pressure and stress
- You have the ability to multi-task in a serious way, with an extreme attention to detail
- You become a representative of the core DNA of the company through who you are
The Position
Earli Inc. is currently seeking a high-caliber Research Associate/Senior Research Associate for LNP Formulation within the Delivery Team.
Your Primary Responsibilities
- Routinely formulate high-quality lipid nanoparticles (LNP) encapsulating DNA that meet specifications for testing in mouse models. Assist in scale-up operations to produce LNP batches for large animal studies
- Employ various mixing technologies (microfluidics, impingement jet mixing, etc.) and downstream operations (dialysis, TFF, etc.) for LNP formulation
- Perform detailed biophysical characterization of LNPs by Dynamic Light Scattering, Fluorescence Spectroscopy, and HPLC to measure LNP size, polydispersity, encapsulation efficiency, lipid composition, API integrity, and potency
- Troubleshoot formulation and equipment challenges using creative and independent problem-solving approaches, using published literature as a guide
- Serve as a single point-of-contact with Earli’s translational biology team to provide formulations for in vivo studies to meet dosing schedules
- Perform mammalian cell culture and in vitro cell-based assays such as reporter gene expression assays to analyze formulation potency
- Perform assays such as quantitative PCR and RT-PCR, luminescence, and ELISA assays from cell/tissue lysates and serum in a reproducible and careful manner
- Document protocols, materials, and results and maintain an extremely thorough electronic laboratory notebook
- Communicate findings internally to team via presentations and written reports.
Your Required Experience, Knowledge and Skill
- BS or MS degree in physical/life sciences or engineering discipline, with >2 years biotech industry experience
- Prior experience with Lipid Nanoparticle formulation with siRNA, mRNA, or DNA using ionizable lipids (not merely off-the-shelf transfection reagents) is required for this role
- Experience with a wide variety of chemical/biochemical research methods (e.g. buffer preparation, protein purification, plate-based absorbance and fluorescence assays) is required
- Experience with mammalian cell culture, cell-based assays (luminescence, fluorescence, etc.) and molecular biology techniques such as nucleic acid extraction/purification and quantitative RT-PCR is preferred
- A ‘self-starter’ mentality with strong motivation and a keen drive to excel individually and in a team
- Excellent verbal communication, organization, time management, and interpersonal skills
- Ability to think independently, multi-task effectively, and fully integrate into a high achieving team environment
If interested in applying, please attach a CV or have a well-developed LinkedIn profile for us to be able to assess your background.
We look forward to hearing from you!
This job is no longer accepting applications
See open jobs at Earli.See open jobs similar to "Research Associate or Senior Research Associate, LNP Formulation" Sands Capital.