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Senior Reliability and Lifecycle Engineer

Karuna Therapeutics

Karuna Therapeutics

Devens, MA, USA
USD 114,100-134,240 / year + Equity
Posted on Aug 8, 2025

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

Position: Senior Reliability and Lifecycle Engineer

Location: Devens, MA

Key Responsibilities

  • Develop new, and improve current, systems, practices, policies, and procedures pertaining to maintenance & operations activities to enhance the performance of the business and establish a continuous improvement philosophy for reliability.
  • Ensure new designs and modifications incorporate reliability, availability, maintainability, operability, safety, and life cycle costing reviews and participates in the development of design and installation specifications along with commissioning & qualification plans.
  • Establish equipment criticality ranking and apply appropriate maintenance philosophies to develop a robust systems lifecycle strategy.
  • Monitor and analyze system failures to increase reliability and reduce life cycle costs.
  • Develop and generate key performance indicators to monitor and optimize systems lifecycle.
  • Drive a reliability program focused on Condition Based Maintenance (CbM) or Predictive Maintenance (PdM, CAL & EM), i.e. laser alignment, thermography, oil analysis, vibration monitoring, ultrasound and the appropriate alarm levels.
  • Determine equipment to be monitored and establish the reliability program for predictive maintenance technologies, i.e. laser alignment, thermography, oil analysis, vibration monitoring, ultrasound and the appropriate alarm levels.
  • Drive timely proactive action (CO) at early stages of failures as identified by the CbM and PdM program.
  • Conduct or lead Failure Mode and Effects Analysis (FMEA) and Reliability Centered Maintenance (RCM) exercises, leading a departmental cross-functional team.
  • Develops the site’s asset investment plan (State of Good Repair), to ensure continuing high equipment reliability while maintaining lowest overall maintenance costs.
  • Identify spare parts requirements and critical spare parts. Support MRO Storeroom in establishing min/max stock levels.
  • Support the creation and modification of documentation to support maintenance activities (Maximo Job Plans, Data Sheets, Work Instructions).
  • Support compliance efforts related to Quality Events, CAPA, change management and contamination investigations.
  • Perform Root Cause Failure Analysis on equipment failures, to increase reliability and reduce life cycle costs.
  • Works with Planning & Scheduling to schedule, oversee job assignments, and lead PdM technicians from a technical perspective.
  • Provide input for departmental budget by allocating expenses bases on site strategies and business unit’s priorities.

Qualifications & Experience

  • B.S. in Engineering (Reliability or Mechanical preferred) with 5 years plus (or equivalent) experience in maintenance and reliability of equipment in the manufacturing industry.
  • The individual should have the ability to manage and organize complex technical projects and possess familiarity with the manufacturing operations of large-scale production facilities as well as GMP experience.
  • Strong knowledge of preventive, predictive maintenance processes and practices to improve equipment reliability.
  • Knowledge of RCM, CMMS (Maximo preferred) and PdM technology software.
  • Knowledge of regulatory, environmental, GMP requirements along with knowledge of manufacturing facilities, utility operations, building maintenance operations.
  • Expertise with typical biopharmaceutical upstream and downstream processing and support equipment including but not limited to scale up and large-scale bioreactors, filtration and ultra-filtration, CIP, SIP, centrifugation, chromatography, autoclaves, and glass washers.
  • Effective in both a team environment and as an individual contributor role.
  • Knowledgeable in engineering principles related to instrumentation in a Biopharmaceutical process troubleshooting.
  • Adaptable to a fast paced, complex, and ever-changing business environment.
  • Ability to effectively communicate verbally and in writing, with cross-functional groups to achieve effective and timely results.

If you come across a role that intrigues you but does not perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

The starting compensation for this job is a range from $114,100.00 USD to $134,240.00 USD plus incentive cash and stock opportunities (based on eligibility).

The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed.

Final, individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit https://careers.bms.com/life-at-bms/.

Benefit offerings are subject to the terms and conditions of the applicable plans then in effect and may include the following: Medical, pharmacy, dental and vision care. Wellbeing support such as the BMS Living Life Better program and employee assistance programs (EAP). Financial well-being resources and a 401(K). Financial protection benefits such as short- and long-term disability, life insurance, supplemental health insurance, business travel protection and survivor support. Work-life programs include paid national holidays and optional holidays, Global Shutdown Days between Christmas and New Year’s holiday, up to 120 hours of paid vacation, up to two (2) paid days to volunteer, sick time off, and summer hours flexibility. Parental, caregiver, bereavement, and military leave. Family care services such as adoption and surrogacy reimbursement, fertility/infertility benefits, support for traveling mothers, and child, elder and pet care resources. Other perks like tuition reimbursement and a recognition program.

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If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers
With a single vision as inspiring as “Transforming patients’ lives through science™ ”, every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to conduct their work. This structure includes site-essential, site-by-design, field-based and remote-by-design jobs. The occupancy type that you are assigned is determined by the nature and responsibilities of your role:

Site-essential roles require 100% of shifts onsite at your assigned facility. Site-by-design roles may be eligible for a hybrid work model with at least 50% onsite at your assigned facility. For these roles, onsite presence is considered an essential job function and is critical to collaboration, innovation, productivity, and a positive Company culture. For field-based and remote-by-design roles the ability to physically travel to visit customers, patients or business partners and to attend meetings on behalf of BMS as directed is an essential job function.

BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to adastaffingsupport@bms.com. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

BMS cares about your well-being and the well-being of our staff, customers, patients, and communities. As a result, the Company strongly recommends that all employees be fully vaccinated for Covid-19 and keep up to date with Covid-19 boosters.

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.